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Search Results for " vero e6 "

16

抑制剂 & 化合物

1

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T60014	SHEN26	Antiviral	Immunology/Inflammation
	SHEN26 具有抗病毒活性，可用于治疗病毒感染的研究。
T0711	Niclosamide BAY2353,Niclocide,氯硝柳胺	Antibiotic; STAT; Parasite	JAK/STAT signaling; Microbiology/Virology; Stem Cells
	Niclosamide (Niclocide) 是一种口服生物可利用的氯化水杨酰苯胺。它通过抑制 DNA 复制，具有驱虫和潜在的抗肿瘤活性。
T1406	Amantadine hydrochloride 盐酸金刚烷胺,1-adamantanamine HCl,1-Adamantanamine hydrochloride,Symmetrel,CI-719,Amantadine HCl,1-Adamantylamine hydrochloride	Dopamine Receptor; Influenza Virus	GPCR/G Protein; Microbiology/Virology; Neuroscience
	Amantadine hydrochloride (CI-719) 是一种抗病毒药物，用于预防或对症治疗甲型流感和帕金森病。它阻断质子流通过 M2 离子通道，从而阻止病毒 RNA 释放到感染细胞的细胞质中。
T37173	MPro Inhibitor 11a
	MProinhibitor 11a is an inhibitor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (MPro; IC50= 0.053 μM in a TR-FRET assay).1It reduces viral yield in the culture supernatant of SARS-CoV-2-infected Vero E6 cells (EC50= 0.53 μM). MProinhibitor 11a also reduces viral RNA copy numbers in the same model when used at concentrations ranging from 1.85 to 50 μM. 1.Dai, W., Zhang, B., Jiang, X.-M., et al.Structure-based design of antiviral drug candidates targeting the SARS-...
T1307	Carmofur HCFU,卡莫氟	Nucleoside Antimetabolite/Analog; Virus Protease; SARS-CoV; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Carmofur (HCFU) 是 5-氟尿嘧啶的衍生物，是一种抗肿瘤药物。它是一种酸性神经酰胺酶抑制剂，用于治疗乳腺癌和结直肠癌。它抑制 SARS-CoV-2主要蛋白酶，还抑制 Vero E6 细胞 SARS-CoV-2，EC50为 24.3 μM。
T72519	Niclosamide sodium BAY2353 sodium
	Niclosamide (BAY2353) sodium 为用于研究寄生虫感染的口服抗蠕虫化合物，同时是STAT3抑制剂，在HeLa细胞中IC50为0.25μM。此化合物显示抗癌生物活性，并可抑制Vero E6细胞DNA复制。
T40207	SARS-CoV-2-IN-7
	SARS-CoV-2-IN-7 demonstrates potent inhibition of viral replication in SARS-CoV-2-infected Vero E6 cells with an IC50 value of 844 nM.
T79661	SARS-CoV-2 3CLpro-IN-18	SARS-CoV	Microbiology/Virology
	SARS-CoV-2 3CLpro-IN-18（Compound 3C）为一种共价SARS-CoV-2 3CLpro抑制剂，具有0.478 μM的IC50值。在Vero E6细胞中对SARS-CoV-2展现出2.499 μM的EC50抑制活性，并显示出较低的细胞毒性（CC50> 200 μM）。
T79329	SARS-CoV-2-IN-56	SARS-CoV	Microbiology/Virology
	SARS-CoV-2-IN-56（Compound 63）是具有抗病毒活性的SARS-CoV-2抑制剂，能在Vero E6 细胞中抑制SARS-CoV-2，其IC50为0.7 μM。
T81209	SARS-CoV-2-IN-62	SARS-CoV	Microbiology/Virology
	SARS-CoV-2-IN-62 (Compound R3b) 为SARS-CoV-2复制抑制剂，细胞毒性较低。在Vero E6细胞和Calu-3细胞中，其抑制病毒复制的EC50值分别为2.97 μM与3.82 μM。
T79328	SARS-CoV-2-IN-54	SARS-CoV	Microbiology/Virology
	SARS-CoV-2-IN-54（Compound 2）为针对SARS-CoV-2的抑制剂，展现出抗病毒活性。它能在Vero E6细胞中抑制SARS-CoV-2，其IC50值为21.4 μM。
T79455	SARS-CoV-2 Mpro-IN-9	SARS-CoV	Microbiology/Virology
	SARS-CoV-2 Mpro-IN-9 (compound c7) 是非肽类、非共价型SARS-CoV-2 Mpro抑制剂，IC50值为0.085 μM，展现出改进的物化特性和药物代谢及药动学 (DMPK) 性质。在Vero E6 细胞中，对SARS-CoV-2感染显示抑制效果，EC50为1.10 μM，同时具备低细胞毒性（CC50>50 μM）。
T36435	SP 10
	Peptide originally derived from SARS-CoV Spike (S) protein; corresponds to amino acid residues 668 to 679. Highly potent inhibitor of SARS-CoV S protein and ACE2 interaction (IC50 = 1.88 nM in biochemical assay). Inhibits interaction of SARS-CoV S protein and Vero E6 cells in vitro. Please note, this peptide displays 80% sequence identity to homologous site on SARS-CoV-2 S-protein (residues 689-697).
T79462	SARS-CoV-2 3CLpro-IN-14	SARS-CoV	Microbiology/Virology
	SARS-CoV-2 3CLpro-IN-14（compound 11j）为口服活性SARS-CoV-2 3CLpro抑制剂，于Vero E6细胞中对SARS-CoV-2展现出高效抗活性（EC50=0.18 μM），且具备低细胞毒性（CC50>50 μM）。
T81208	SARS-CoV-2-IN-63	SARS-CoV	Microbiology/Virology
	SARS-CoV-2-IN-63（Compound R3e）是一种针对SARS-CoV-2病毒复制的抑制剂，具备较低的细胞毒性。在Vero E6细胞和Calu-3细胞中对SARS-CoV-2的抑制作用表现出EC50值分别为1.99 μM与1.92 μM。
T37174	SARS-CoV MPro-IN-1
	MProinhibitor 11b is an inhibitor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (MPro; IC50= 0.04 μM in a TR-FRET assay).1It reduces viral yield in the culture supernatant of SARS-CoV-2-infected Vero E6 cells (EC50= 0.72 μM). MProinhibitor 11b also reduces viral RNA copy numbers in the same model when used at concentrations ranging from 1.85 to 50 μM. 1.Dai, W., Zhang, B., Jiang, X.-M., et al.Structure-based design of antiviral drug candidates targeting the SARS-C...

化合物

Cat.No: T60014

Target: Antiviral

Cat.No: T0711

Synonym: BAY2353,Niclocide,氯硝柳胺

Target: Antibiotic, STAT, Parasite

Amantadine hydrochloride

Cat.No: T1406

Synonym: 盐酸金刚烷胺,1-adamantanamine HCl,1-Adamantanamine hydrochloride,Symmetrel,CI-719,Amantadine HCl,1-Adamantylamine hydrochloride

Target: Dopamine Receptor, Influenza Virus

MPro Inhibitor 11a

Cat.No: T37173

Cat.No: T1307

Synonym: HCFU,卡莫氟

Target: Nucleoside Antimetabolite/Analog, Virus Protease, SARS-CoV, DNA/RNA Synthesis

Niclosamide sodium

Cat.No: T72519

Synonym: BAY2353 sodium

SARS-CoV-2-IN-7

Cat.No: T40207

SARS-CoV-2 3CLpro-IN-18

Cat.No: T79661

Target: SARS-CoV

SARS-CoV-2-IN-56

Cat.No: T79329

Target: SARS-CoV

SARS-CoV-2-IN-62

Cat.No: T81209

Target: SARS-CoV

SARS-CoV-2-IN-54

Cat.No: T79328

Target: SARS-CoV

SARS-CoV-2 Mpro-IN-9

Cat.No: T79455

Target: SARS-CoV

Cat.No: T36435

SARS-CoV-2 3CLpro-IN-14

Cat.No: T79462

Target: SARS-CoV

SARS-CoV-2-IN-63

Cat.No: T81208

Target: SARS-CoV

SARS-CoV MPro-IN-1

Cat.No: T37174

Cat. No.	Product Name	Target	Signaling Pathways
T7060	Amantadine 1-Aminoadamantane,1-金刚烷胺,金刚烷胺,1-Adamantanamine,1-Adamantylamine	Others	Others
	Amantadine (1-Aminoadamantane) 是抗病毒药物，也是是 NMDA 型谷氨酸受体的弱拮抗剂，能促进高多巴胺的释放，并阻断多巴胺的再摄取。

天然产物

Cat.No: T7060

Synonym: 1-Aminoadamantane,1-金刚烷胺,金刚烷胺,1-Adamantanamine,1-Adamantylamine

Target: Others

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